132 articles - From Friday Sep 05 2025 to Friday Sep 12 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gut |
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Screening and eradication of <i>Helicobacter pylori f</i>or gastric cancer prevention: Taipei Global Consensus II. Objective To convene a global consensus on eradication is an effective prevention strategy for gastric cancer that should be offered to al infected adult individuals. Future research should prioritise determining the optimal timing for screening, evaluating long term individual and population outcomes, as well as identifying more precise risk stratification parameters. |
| J Hepatol |
The barriers for uptake of artificial intelligence in hepatology and how to overcome them. In particular, we argue that the use of AI in clinical trials, seamless integration into hospital information systems and building AI literacy among clinicians will ultimately drive clinical adoption. We validate this perspective through a Delphi consensus involving 34 international experts from hepatology, AI, and data science, ensuring a comprehensive and consensus-driven evaluation of our recommendations. |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
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Incidence of Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Reconstructed Individual Patient Data Meta-Analysis. This reconstructed individual participant data meta-analysis provides updated estimates for HCC incidence in people with MASLD. The incidence of HCC is elevated in people with MASLD and advanced fibrosis. These data may have implications for further research in HCC surveillance and future development of surveillance algorithms. |
| Endosc Int Open |
Artificial Intelligence-Assisted Colonoscopy With or Without Mucosal Exposure Device for Detection of Colorectal Adenomas: A Meta-Analysis. Endocuff combined with AI was superior to AI alone in improving the adenoma detection rate without increasing intubation or withdrawal times. |
Peroral cholangioscopy for detecting residual stones missed by cholangiography: Systematic review and meta-analysis. POC identified residual stones in over one-fourth of patients following negative cholangiography. Detection rates were highest with digital systems. The procedure demonstrated a strong safety profile and may play an important role in confirming complete ductal clearance. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Comparative Risk of Hepatitis B Virus Reactivation in Patients Receiving Immune Checkpoint Inhibitors or Tyrosine Kinase Inhibitors for Liver Cancer. With adequate antiviral prophylaxis, the absolute risk of HBVr is low in advanced HBV-related liver cancer patients receiving ICI, regardless of current or past HBV infection. |
Prediction of Hepatocellular Carcinoma and Other Liver-Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction-Associated Steatotic Liver Disease. CHB patients with metabolic dysfunction and/or MASLD are at significant risk of HCC. The PAGE-B score can be used to stratify HCC risk in this population, with negligible 5-year HCC incidence in those without cirrhosis and low PAGE-B scores. However, caution should be exercised in patients with cirrhosis in whom HCC risk remains significant even among those with a low PAGE-B score. |
Research Communication: Combination Therapy of Upadacitinib With Infliximab, Risankizumab, Ustekinumab or Vedolizumab for Refractory Crohn's Disease: A Descriptive Case Series. Adverse events occurred in 13 patients, leading to treatment discontinuation in three. Combining upadacitinib with a biologic appeared effective and safe, warranting further investigation in prospective studies. |
| Clin Gastroenterol Hepatol |
Defining non-invasive criteria for indicating drug therapy in metabolic-associated steatotic liver disease in clinical practice. The diagnostic performance and reliability of the proposed non-invasive criteria for initiating resmetirom treatment were suboptimal.About the half of patients with indication would not receive treatment under these criteria.A new strategy, using FIB-4, the presence of diabetes and overweight, and liver stiffness improved the identification of MASLD patients with fibrosis stage 2-3. |
Effectiveness and Safety of Orodispersible Budesonide for Eosinophilic Esophagitis: A Multicenter Real-World Study. Our real-world data confirm that BOTs are effective in inducing clinical and histologic remission in most EoE patients. The drug has a good safety profile, with side effects occurring only in a small number of patients. |
Infliximab and ustekinumab clearance better predict endoscopic outcomes than trough concentrations in Crohn's disease. Methods Data from patients with moderate-to-severe CD starting infliximab (n=108) and ustekinumab (n=80) therapy were repurposed. Endoscopic remission (CD Endoscopic Index of Severity loses its ability to predict treatment response when doses are optimized or not administered by bodyweight, infliximab and ustekinumab clearance remain a reliable predictor for endoscopic outcomes. |
Real-world use of terlipressin in cirrhosis and acute kidney injury: frequent use beyond hepatorenal syndrome. Terlipressin is often used for treatment of AKI outside its primary indication of HRS-AKI. Compared to patients with HRS-AKI, response to terlipressin is significantly lower in patients with ATN, in whom the risks may outweigh the benefits. Respiratory failure is common, but does not seem to be driven by the amount of albumin received nor ACLF grade. |
Reliability and Responsiveness of Endoscopic Indices for Assessing Crohn's Disease Postoperative Recurrence in the PREVENT trial. Existing endoscopic indices are reliable and responsive for assessing postoperative CD activity in the neoterminal ileum, although are suboptimal for evaluation in the anastomosis or distal colonic segment. |
Socioeconomic disparity and risk of irritable bowel syndrome: a cohort study with mediation analysis. Higher SES is associated with reduced risk of incident IBS with mediation effect of healthy lifestyle factors. Interventions targeting both SES inequalities and lifestyle improvements may help reduce IBS burden. |
Supplementary Material for Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data from Nine Countries. Work productivity losses are projected to more than double in most countries, and health-related quality of life will decline modestly as the burden of advanced disease increases CONCLUSIONS: Without intervention, the clinical, economic, and quality-of-life burden of MASH is projected to increase across most regions of the world. These findings highlight the urgent need for both national and global strategies to reduce the negative impact of MASH on individuals and society. |
| Endosc Int Open |
Assessing outcomes of full-thickness resection in piecemeal polypectomy scar consolidation of colon adenomas containing cancer. EFTR could offer endoscopists a safe, efficacious, and minimally invasive mechanism for formal tumor (T) staging of malignancies found within polypectomy segments. Further studies with larger sample sizes are needed to assess outcomes in patients with residual neoplastic disease. |
Comparison of three electrosurgical modes for endoscopic mucosal resection of 10- to 20-mm colorectal polyps: Randomized controlled trial. Endocut Q (effect 2, effect 3 and effect 4) was effective and safe for removing 10- to 20-mm non-pedunculated colorectal polyps. However, effect 2 may be superior to effect 3 and effect 4 in reducing intra-procedural bleeding. |
Fully-covered metal stent removal failure in case of non-malignant biliary strictures: Risk factors and resolution technique. FC-SMES-in-FC-SEMS technique appears to be safe and effective to overcome FC-SEMS removal failure in patients with non-malignant distal biliary strictures. Reducing dwell stenting period, especially in patients with personal history of previous biliary stenting, may reduce risk of FC-SEMS removal failure. |
Influence of a defoaming agent - simethicone - on endoscope cleaning and disinfection: Prospective real-world study. Simethicone may remain in the biopsy and water infusion channels, regardless of whether it is used or not. It is recommended to utilize a simethicone concentration of 1% or less when administering it through the biopsy or auxiliary water channels of the endoscope. |
Preventive wound drainage reduces esophageal fistula or infection after endoscopic resection of giant submucosal tumors in the esophagus. In the context of STER for giant esophageal submucosal tumors with muscular layer full-thickness resection and mucosal injury, preventive drainage is an effective strategy for minimizing postoperative esophageal fistula and submucosal infection complications. |
Push enteroscopy and colonoscopy in melena patients with negative esophagogastroduodenoscopy: Prospective multicenter study. PE is beneficial for patients with melena and nondiagnostic EGD. It should be considered before or in combination with colonoscopy for these patients. |
Transoral incisionless fundoplication for patients with gastroesophageal reflux disease after peroral endoscopic myotomy: Prospective cohort. Use of TIF seems to be a feasible alternative for treating GERD after POEM, improving both clinical and endoscopic parameters and pHmetry in a considerable percentage of cases. |
Yield of next-generation sequencing in diagnostic work up of suspicious biliary strictures. NGS in brushes contributed to more accurate/sensitive diagnoses of malignancy than morphology alone. There was a limited impact on CDM change, but in the future, NGS will undoubtedly play a bigger role when targeted therapy is incorporated in standard treatment and more sensitive NGS panels for cholangiocarcinoma are developed. |
| Endoscopy |
Colon capsule endoscopy compared to conventional colonoscopy in patients with colonic diverticulitis: a randomised controlled superiority trial. CCE is a safe procedure for follow-up in patients after an episode with CD and is preferred by a majority of the patients compared to colonoscopy, but those receiving both modalities differed. |
Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative - Update 2025. Patients undergoing a diagnostic UGI endoscopy should have their experience measured using a validated scale, to promote a patient-centered and quality-driven environment. Patients with nondysplastic BE or gastric precancerous conditions in an endoscopic surveillance program should be monitored for guideline interval adherence. |
| Gastroenterology |
The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder Symptoms in Adults With Disorders of Gut-Brain Interaction: A Population-Based Study. Positive ARFID screens are common in DGBI and associated with increased general health burden. Routine screening for ARFID in DGBI will inform the multi-integrated care plan provided by clinicians, dietitians, and psychologists. |
| Gastrointest Endosc |
Anatomical location of colorectal neoplasia in patients with positive stool tests (mt-sDNA or FIT): Data from the New Hampshire Colonoscopy Registry. Our data suggest that FIT+ tests are associated with higher detection of both right- and left-sided AAs when compared to colonoscopy without a prior stool test. Furthermore, mt-sDNA+ patients had higher rates of left and right-sided AAs and ASPs, particularly on the right side. |
Effectiveness of Self-Assembling Peptide in Reducing Bleeding After Colorectal Endoscopic Submucosal Dissection. The application of SAP significantly reduced the occurrence of hematochezia and DB after colorectal ESD. Furthermore, SAP was a significant factor associated with the reduction of hematochezia and DB. Therefore, SAP may be appropriate for the prevention of post-ESD bleeding in the colon. |
LONG-TERM FOLLOW-UP OF PATIENTS UNDERGOING CHOLANGIOPANCREATOSCOPY-GUIDED LASER DISSECTION AND ABLATION FOR REFRACTORY PANCREATIC AND BILIARY STRICTURES. CPL has high technical success and an acceptable safety profile for the treatment of benign refractory BD and PD strictures. |
| Gut |
Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells. These findings reveal a novel mechanism by which fructose fosters tumour progression through the modulation of tumour-stroma interactions, and highlight the therapeutic potential of targeting fructose metabolism in CRC to disrupt the tumour-stroma crosstalk that drives malignancy. |
| Hepatology |
Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles. Contrary to our original goal, we unexpectedly found that polyIC-LNPs function as an efficacious monotherapy tailored for liver cancer, capable of coordinately modulating antitumor immunity. This novel approach eliminates the need for ICIs, thereby addressing key limitations of current immunotherapies. |
IL1β Signaling Mediates the Interaction Between Hepatitis B and C Viruses. Our findings reveal a macrophage-derived, IFN-independent mechanism by which HCV suppresses HBV infection, mediated through IL1β. These insights highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that targeting IL1β-regulated pathways may offer therapeutic potential to prevent HBV reactivation in DAA-treated patients. |
Natural history and development of a novel composite endpoint in patients with alcohol-associated Hepatitis: Data from a prospective multicenter study. This large observational study showed a high incidence of composite liver and alcohol-use events within six months, reiterating the need for early interventions. |
| J Hepatol |
S1P/S1PR4 Promotes the Differentiation of CD8<sup>+</sup> tissue-resident memory T Cells Aggravating Bile Duct Injury in Biliary Atresia. The S1 subtype of BA, characterized by dysregulated immune pathways and poor prognosis, was identified. S1P/S1PR4 signaling promotes cholangiocyte injury via promoting CX3CR1 + CD8 + Teff migration and their differentiation into apoptosis-inducing CD8 + TRM cells. Impact and implications Our study bridges a critical knowledge gap in biliary atresia (BA) pathogenesis by defining how sphingolipid-driven CD8 + TRM differentiation via S1P/S1PR4 signaling exacerbates bile duct injury, establishing the mechanistic link between immunometabolic dysregulation and BA progression. These findings are essential for pediatric hepatologists and immunologists, as they identify the S1 molecular subtype (characterized by poor prognosis and immune hyperactivation) as a high-risk population warranting precision intervention. For patients, S1PR4 inhibition (CYM50358) experimentally reduces biliary obstruction and improves survival in BA mouse models, supporting its prioritization for clinical trials especially in S1-subtype BA. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
Biopsychosocial and Environmental Factors that Impact Brain-Gut-Microbiome Interactions in Obesity. By recognizing and addressing the impact of various SDOH on BGM interactions, healthcare providers can provide a more equitable and personalized approach that will enhance treatment adherence and the quality of life for individuals with obesity. |
| Endosc Int Open |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Gut |
| J Hepatol |